http://repository.uhamka.ac.id/id/eprint/15935/ Anti-obesity Potency of Chili Extract in Male White Rat Siska, Siska Obesity is a global epidemic for non-communicable diseases characterized by a body mass index more than 30 kg/m2 . Epidemiological data show that consuming foods containing capsaicin, the main active compound and causes a spicy taste in chili associated with a decrease in the prevalence of obesity. This study aims to determine the effect of consumption chili on lipid profile of rats fed high-fat diet and their potential as anti-obesity. Treatment was conducted on 24 male Sprague-Dawley rats and divided into 6 groups namely the regular group (N) was given a standard diet and the group that was given a high�fat diet (PTL) and varied with a dose of 0.5 g/kg BW. Every 14 days of treatment, the weight of the rats was weighed, and blood was taken retro-orbital to obtain the serum. The rat serum was tested for total cholesterol (TC), triglycerides, LDL, and HDL through the colorimetric method. The levels were assessed using a clinical spectrophotometer. The results showed a decrease in weight, LDL, increase HDL (p<0>0.05). This showed chili extract has the potential as an anti-obesity with parameters of measuring lipid profile and weight but needs dose adjuster and timing of extract administration. http://repository.uhamka.ac.id/id/eprint/15935/1/SISKA_IJPST_2022.pdf Unduh!